For each of the Microfluidics physics interfaces, the underlying physical principles are expressed in the form of partial differential equations, together with corresponding initial and boundary conditions. COMSOL’s design emphasizes the physics by providing users with the equations solved by each feature and offering the user full access to the underlying equation system. There is also tremendous flexibility to add user-defined equations and expressions to the system. For example, to model the transport of a species that significantly affects the viscosity of the fluid, simply type in a concentration-dependent viscosity — no scripting or coding is required (this is demonstrated in the Tutorial Model: A Controlled Diffusion Separator). When COMSOL Multiphysics compiles the equations, the complex couplings generated by these user-defined expressions are automatically included in the equation system. The equations are then solved using the finite element method and a range of industrial-strength solvers. Once a solution is obtained a vast range of postprocessing tools are available to interrogate the data, and predefined plots are automatically generated to show the device response. COMSOL Multiphysics offers the flexibility to evaluate a wide range of physical quantities including predefined quantities such as the pressure, velocity, shear rate, or the vorticity (available through easy-to-use menus), as well as arbitrary user-defined expressions.