This chapter provides an overview of the different ways that you can run the COMSOL Multiphysics® software in addition to running the COMSOL Desktop® graphical user interface on a dedicated computer, including client-server and distributed-memory architectures. For information about COMSOL Server™ and running COMSOL Multiphysics applications as a client, see the COMSOL Server Manual. COMSOL Multiphysics and COMSOL Server support cloud computing. See https://www.comsol.com/running-comsol-software-in-the-cloud.