This chapter provides an overview of the different ways that you can run the COMSOL Multiphysics® software in addition to running the COMSOL Desktop® graphical user interface on a dedicated computer, including client-server and distributed-memory architectures. For information about COMSOL Server and running COMSOL Multiphysics applications as a client, see the COMSOL Server Manual. For information about using COMSOL Multiphysics with the Amazon Elastic Compute Cloud™, go to www.comsol.com/ec2_manual.